Is your protocol
working?
Protocol Adherence tells you what you did. Protocol Efficacy tells you if it's moving the needle — using the biomarkers that actually change when a protocol is working.
[SEC_01] How It Works
Per-marker breakdown. No composite scores.
Protocol Efficacy displays each relevant biomarker individually — value, direction, and population percentile. The overall direction (↑ → ↓) is derived from the majority of available markers trending up, stable, or down.
A composite score would require arbitrary weighting across incomparable markers (HRV vs VO₂ max vs CRP) and becomes a black box you can't interpret or trust. Showing each marker individually is more honest, more useful, and lets you see exactly what's moving and what isn't.
If you have no markers logged yet, the tracker shows what's being measured and what to log next. No dead zone — you see what's being tracked from Day 1.
Overall Direction
Improving
Majority of markers trending up
Stable
Markers holding position
Declining
Majority of markers trending down
[SEC_02] Category-Specific Measurement
The right markers for your protocol type.
Protocol Efficacy is one metric name with category-specific measurement underneath. The same concept — "is your protocol working?" — is answered differently per protocol category, using the markers that actually respond to each intervention type.
Longevity Protocol
Blueprint, Performance Longevity, Longevity Basics
Cardiovascular & Fitness
HRV
Heart Rate Variability — a widely used marker of autonomic nervous system function and recovery. Synced from Oura, WHOOP, Apple Health, Health Connect or Google Health.
Resting Heart Rate
Elite athletes typically sit below 50 bpm. Auto-synced from wearables or logged manually.
VO₂ Max (ml/kg/min)
Among the strongest predictors of all-cause mortality in cohort studies. Estimated by Apple Watch and WHOOP (Garmin via Apple Health / Health Connect), or field-tested (Cooper test, treadmill VO₂). Age-adjusted percentile shown.
Heart Rate Recovery (HRR)
Bpm drop in the first 60 seconds post-exercise. A direct readout of cardiac fitness and parasympathetic tone. Logged after a workout session.
Blood Pressure
Systolic/diastolic trend. Logged via home cuff or manual entry. Target: ≤120/80 mmHg.
Grip Strength (kg)
Associated with all-cause mortality in large cohort studies. Measured with a hand dynamometer (~$25). Age + sex percentile shown.
Body Composition
Body Fat %
Measured via DEXA scan, smart scale (InBody/Withings), or Navy tape method. DEXA is the reference method.
Bone Mineral Density (g/cm²)
Measured by DEXA scan — same scan as body fat. Results extracted from uploaded DEXA report PDF. T-score and Z-score tracked.
Lab Markers (from uploaded results)
hsCRP & Inflammatory Panel
High-sensitivity CRP, homocysteine, IL-6. Low-grade inflammation is linked to many age-related diseases. Longevity-optimal target: below 0.5 mg/L.
ApoB / LDL-C
ApoB counts the particles that drive atherosclerosis risk. More precise than LDL-C. Standard lipid panel + ApoB ordered together. Extracted from uploaded lab PDF.
Testosterone & DHEA-S
Hormonal markers that decline with age and respond to lifestyle interventions (sleep, Zone 2, strength training). Both measured from a standard blood draw.
VEGF (pg/mL)
Vascular Endothelial Growth Factor — marker of vascular function and angiogenesis. Ordered as an add-on to a standard blood panel via Quest or LabCorp.
Fasting Glucose & HbA1c
Fasting glucose logged daily (CGM or finger stick); HbA1c from quarterly lab draw.
Biological Age Markers — Emerging
These tests exist but require specialized labs, are expensive, and have long turnaround times. Kinosis tracks them when results are available — they appear in your efficacy timeline as point-in-time anchors, not daily metrics.
Epigenetic Clock (DunedinPACE)
Speed of biological aging per calendar year (1.0 = average pace). Via TruAge, Elysium Index. ~$200–400.
Telomere Length
Measured via TeloYears or Life Length. High variance — trend across multiple tests is more informative than any single result.
Horvath / GrimAge Clock
DNA methylation-based biological age. Among the strongest lifespan predictors in current epigenetic research. Available via TruAge Complete.
Metabolic / Weight Loss Protocol
GLP-1 (Ozempic, Mounjaro), diabetes management
Fasting Glucose
Daily fasting blood glucose — a daily readout of glucose control. Target: below 100 mg/dL.
HbA1c
3-month average blood glucose. A standard marker for tracking GLP-1 efficacy. Updated from lab uploads.
Body Composition
Weight trend plus body fat percentage when available. Lean mass preservation during weight loss is tracked separately.
Blood Pressure
Systolic/diastolic trend. Hypertension commonly improves with metabolic protocols — logged manually or from wearable.
Athletic / Performance Protocol
Zone 2 Athlete, endurance, strength
VO₂ Max
Peak aerobic capacity — a core endurance marker. Measured via wearable or field test estimate.
Heart Rate Recovery (HRR)
Bpm drop in first 60 seconds post-exercise. A 20+ bpm drop indicates good cardiovascular fitness.
HRV
Training readiness signal. Low HRV the morning after a hard session indicates incomplete recovery — useful for load management.
Recovery Rate
How quickly resting HR and HRV return to baseline after hard training blocks. Reflects overall recovery capacity.
Chronic Disease Protocol
Autoimmune, cardiovascular, diabetes management
Symptom Frequency
How often symptoms occur over a rolling 30-day window. Downward trend is the primary efficacy signal for disease management protocols.
Symptom Severity
Average severity (1–10 scale) across logged symptom events. Tracked alongside frequency to distinguish fewer-but-worse vs. more-but-milder.
hsCRP
High-sensitivity C-reactive protein — a widely used, clinically validated inflammatory marker. From lab uploads. Low cardiovascular risk: below 1.0 mg/L.
Inflammatory Markers
ESR, IL-6, TNF-α — extracted from uploaded lab reports and tracked longitudinally alongside symptom severity.
General / Custom Protocol
Longevity Basics, custom targets
All available markers
For general protocols, Efficacy draws on all markers with enough data — HRV, resting HR, weight trend, sleep quality, symptom log — and shows each individually. Direction is from the majority of those trending up.
Resting Heart Rate
Resting HR is a simple, broadly available fitness proxy. Downward trend indicates improving cardiovascular health.
[SEC_03] Data Sources
Where the markers come from.
Efficacy markers are pulled from all logged sources — wearables, manual logs, and uploaded lab reports. The more sources connected, the more complete the picture. See everything Kinosis tracks →
Wearables
- · Oura Ring — HRV, resting HR, sleep stages
- · WHOOP — HRV, HRR, strain, recovery
- · Apple Health — VO₂ max, HRR, steps
- · Health Connect — HRV, resting HR, steps
- · Google Health — HRV, resting HR, sleep
- · Garmin — via Apple Health / Health Connect
Manual Logs
- · Glucose (CGM or finger stick)
- · Blood pressure (home monitor)
- · Weight and body composition
- · Symptom severity and frequency
Lab Reports
- · Upload PDF — Kinosis extracts the values
- · HbA1c, hsCRP, ApoB, testosterone
- · Full metabolic panel, CBC, lipids
- · Trend tracked across sequential uploads
[SEC_04] Privacy
Your markers are yours.
All Efficacy markers are private by default. No individual data is ever shared or visible to other users. Population percentiles are computed from aggregated, anonymized distributions — no individual-level data is exposed in that calculation.
With your consent, your care team sees your marker history in the Providers Portal, by role.
Providers: follow each patient's markers in the Providers Portal — see For providers.
Start measuring
Your protocol. Your data. Your outcome.
Start logging. As your marker data grows, Protocol Efficacy fills in automatically — no manual setup required.